There's no clear winner between the Toyota Sienna and the Honda Odyssey with respect to transporting cargo. The Honda Odyssey will doubtless prove more convenient than the Sienna for those of you with frequent child-cargo.
The Honda Odyssey is a little more ponderous than the Toyota Sienna. The Toyota Sienna's tank is roughly the same size as the Odyssey's, though the Honda's is slightly more capacious. The Toyota Sienna and the Honda Odyssey compete for the same parking spaces.
You will very likely have to visit your friendly gas station more often with the Toyota Sienna than with the Honda Odyssey.
The destination charge is a standard charge for transporting the vehicle from its point of origin to the dealer. It costs approximately the same to get the Honda Odyssey to the dealership as the Sienna. With respect to fuel economy, the Honda Odyssey and the Toyota Sienna don't differ much. Producing an exact gas mileage evaluation is so tricky that some think not even the federal government can do it, but it looks as though both the Honda Odyssey and the Honda Odyssey perform approximately comparably as far as fuel economy. When it comes to MSRP, the Sienna costs considerably less than the Honda Odyssey.
The Honda Odyssey and the Sienna have about comparable tires. With their comparable turning circles, the Honda Odyssey and the Sienna most definitely handle approximately the same into and out of tight spots.
The Toyota Sienna's engine is a tad smaller than the Honda Odyssey's, but not terribly so. The Toyota Sienna has no lessons to learn with respect to pickup from the Honda Odyssey.
Taller drivers will quite a bit enjoy the extra head room in the Sienna's front cabin compared to the Honda Odyssey. While the rear of the Toyota Sienna offers a bit more head- and leg-room than the Honda Odyssey, there frankly isn't much of a difference.
The Honda and the Toyota Sienna have the same basic after-sale protection.